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New player in cancer’s spread
When people hear that they might have cancer, perhaps the only thing more frightening than the C word is the M word. Metastatic disease — in which the tumor has traveled beyond its primary place to other spots in the body — is responsible for nine out of every 10 cancer deaths.
Recently an unexpected player in this process has emerged: a common bacterium. Fusobacterium nucleatum, which normally lives harmlessly in the gums, appears to have a role in the spread of some cancers of the colon, esophagus, pancreas and — possibly — breast. Laboratory studies and evidence in patients indicate that the microbe can travel through the blood and infect tumor cells by attaching to a sugar molecule on their surface. There it provokes a range of signals and immune responses known to cause tumor cells to migrate. If further confirmed, the work with F. nucleatum could add to a growing understanding of how the microbiome influences cancer progression and may even point the way to fresh approaches to treatment.
(Claudia Wallis. Scientific American, outubro de 2020. Adaptado.)
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